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What is the best treatment for limited vitiligo vulgaris/generalised vitiligo?
| Lead Investigators: | Maxine Whitton, Vitiligo Society |
| Dr Viktoria Eleftheriadou, University of Nottingham | |
| Dr Kim Thomas, University of Nottingham | |
| Details of the research: |
Following publication of a recent Cochrane review of treatments for vitiligo there is little evidence to support the current limited treatments. A trial will not be developed until a prioritisation process has been completed. This will be undertaken by the Centre of Evidence Based Dermatology, in collaboration with the James Lind Alliance, to identify the most important and achievable research projects to be undertaken in the field. A nationwide survey has been conducted, the results of which will be available soon. To keep up to date with developments go to the dedicated website http://www.vitiligostudy.org.uk |
If you would like further details about this prioritsation work please contact Dr Viktoria Eleftheriadou.
- TREBL: Study of trimethoprim for wound healing of patients with epidermolysis bullosa (EB)
| Lead investigator: | Dr Jemima Mellerio, London |
| Interventions: | Trimethoprim, dosage and comparitor to be decided |
| Outcomes: | To be decided |
| Justification for the trial: |
A pilot study is to be undertaken to assess the feasibility of the main trial. |
If you would like further details about this study, or would like to help with recruitment, please contact Margaret McPhee.
- Can statins be used to treat psoriasis?
Lead Investigator: Dr Katherine Finucane, Bristol
Intervention: Statin (to be decided) versus placebo
Outcomes: Improvement in PASI by 50% and a change in DLQI.
Status: A feasibility study has been recommended for this idea. Please contact Margaret McPhee for more information about this study.
- Does early treatment of acne affect the severity in later life?
Lead Investigator: Dr Alison Layton, Harrogate
Intervention: To be decided
Status: Approved for development. If you would like more information about this study please contact Dr Carron Layfield.
- Skin Cancer Prevention: Does topical field-directed treatment of skin bearing multiple actinic keratosis reduce subsequent development of invasive SCC?
Lead Investigator: Dr Charlotte Proby, Ninewells Hospital, Dundee
Interventions: Topical treatment of precancerous field change on sun exposed areas of skin bearing multiple actinic keratoses with 5% imiquimod cream or with 5% fluorouracil cream or with 3% diclofenac gel and comparison with supervised use of high sun-protection factor sunscreen alone.
Outcomes: Rate of development of cutaneous SCC over 12 months. Clearance of actinic keratoses (AK) at six months and persistance of clearance over one year. The cost effectiveness of these therapies, in terms of AK clearance.
A feasibility study has been recommended for this research idea. Dr Proby is currently seeking funding from HTA. Please contact Margaret McPhee if you would like more information about this study.
