- Is clobetasol propionate ointment or tacrolimus ointment most effective as the first line therapy for Erosive Lichen Planus affecting the vulva?
Lead Investigator: Ruth Murphy, Queens Medical Centre, Nottingham
Interventions: To be decided
Outcomes: To be decided
Jusitfication for the trial: Therapautic interventions for erosive lichen planus is a poorly researched area. A Cochrane review will be undertaken to inform this research idea. If you would like more information on this study idea please contact Joanne Chalmers.
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What is the best treatment for limited vitiligo vulgaris/generalised vitiligo?
| Lead investigator: | Maxine Whitton, Vitiligo Society |
| Interventions: | To be decided |
| Outcomes: | To be decided |
| Justification for the trial: |
Following publication of a recent Cochrane review of treatments for vitiligo there is little evidence to support the current limited treatments. A trial will not be developed until a prioritisation process has been completed. This will be undertaken by the Centre of Evidence Based Dermatology, in collaboration with the James Lind Alliance, to identify the most important and achievable research projects to be undertaken in the field. |
If you would like further details about this prioritsation work please contact Clare Lushey.
- Skin Cancer Prevention: Does topical field-directed treatment of skin bearing multiple actinic keratosis reduce subsequent development of invasive SCC?
Lead Investigator: Dr Charlotte Proby, Ninewells Hospital, Dundee
Interventions: Topical treatment of precancerous field change on sun exposed areas of skin bearing multiple actinic keratoses with 5% imiquimod cream or with 5% fluorouracil cream and comparison with supervised use of high sun-protection factor sunscreen alone.
Outcomes:
- Clearance of actinic keratoses over 6 months and persistence of clearance over 2 years.
- Reduction in numbers of keratinocyte skin cancers developing at 3 years, 5 years and 10 years.
A feasibility study has been recommended for this research idea. Funding applications are being drafted. Please contact Joanne Chalmers if you would like more information about this study.
