University of Nottingham





Annual Report 2023 (pdf) (online version)

See annual report or Completed studies page for publication links


 Annual Report 2022

Celebrating 20 years of the UK DCTN in the Clinical and Experimental Dermatology journal:

Paper 1 Impact and outputs from the UKDCTN

Paper 2 Education and research capacity building initiatives




Annual Report 2021 - 20 year anniversary edition

Featured publications:

Anakinra for Palmoplantar Pustulosis: Results from a Randomized, Double-Blind, Multicentre, Two-Staged, Adaptive Placebo-Controlled Trial (Apricot)  S Cro, VR Cornelius, AE Pink et al.

Surgical Management of Hidradenitis Suppurativa in the United Kingdom: A National Survey of Care Pathways Informing the Theseus Study R Howes, JR Ingram, KS Thomas, F Collier, and JN Rodrigues.

Test-guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST) Matthew J. Ridd et al.


Annual Report 2020

Featured Publications:

Randomised controlled trial of topical corticosteroid and home‐based narrowband UVB for active and limited vitiligo – results of the HI‐Light Vitiligo trial

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial


2019 annual report

The report includes our 2018/2019 publications listing.  Featured publication: 

The top ten research priorities for psoriasis in the UK; Results of a James Lind Alliance priority setting partnership. 
Br J Dermatol. 2019 Oct;181(4):871-873


The 2017/2018 UK DCTN Annual report is available here and includes a full list of our publications.

Featured publications:

Doxycycline compared with prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial. Br J Dermatol, 178, 415-423.

Effect of topical imiquimod as primary treatment for lentigo maligna: the LIMIT-1 study. Br J Dermatol, 176, 1148-1154.


The 2016/2017 UK DCTN Annual report is available here and includes our 2017 publications listing.

Featured publications:

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial (BLISTER Study) The Lancet

Wake EV, Batchelor J, Lawton S, Thomas KS, Harrison EF, Cowdell FC; UK Dermatology Clinical Trials Network's CLOTHES Trial Team.Br J Dermatol. 2017 Aug 30. doi: 10.1111/bjd.15909. [Epub ahead of print] The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHES randomised controlled trial 


The 2015/2016 annual report is available here and includes our 2016 publications listing.

Featured publications:

Thomas, K. S., Ormerod, A. D., Craig, F. E., & U. K. Dermatology Clinical Trials Network's STOP GAP Team. (2016). Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. J Am Acad Dermatol

Marsden, J. R., Fox, R., Boota, N. et al. (2016) Effect of topical imiquimod as primary treatment for lentigo maligna - the LIMIT-1 study. Br J Dermatol


Ormerod AD, Thomas KS, Craig FE et al. Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial. BMJ 2015; 350: h2958.

CHALMERS, J. R., LAYFIELD, C. & WILLIAMS, H. C. 2015. Developing a dermatology clinical trials network for improved therapeutics and clinical outcomes research. Current Dermatology Reports, 4, 90-95.

CHALMERS, J. R., WOJNAROWSKA, F., WILLIAMS, H. C. & GROUP, B. S. 2015. A randomized controlled trial to compare the safety and effectiveness of doxycycline (200 mg daily) with oral prednisolone (0.5 mg kg daily) for initial treatment of bullous pemphigoid: a protocol for the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) Trial. Br J Dermatol.

ELEFTHERIADOU, V., THOMAS, K., VAN GEEL, N., & VITILIGO GLOBAL ISSUES CONSENSUS GROUP 2015. Developing core outcome set for vitiligo clinical trials: international e-Delphi consensus. Pigment Cell Melanoma Res, 28, 363-9.

EZZEDINE, K., ELEFTHERIADOU, V., WHITTON, M. & VAN GEEL, N. 2015. Vitiligo. Lancet.

GEORGE, S. M. & MAKRYGEORGOU, A. 2015. 8th Georg Rajka International Symposium on Atopic Dermatitis: meeting report. Br J Dermatol, 172, 916-25.

KIRTSCHIG, G., VAN MEURS, T. & VAN DOORN, R. 2015. Twelve-week treatment of lentigo maligna with imiquimod results in a high and sustained clearance rate. Acta Derm Venereol, 95, 83-5.

MADHOK, V., FUTAMURA, M., THOMAS, K. S. & BARBAROT, S. 2015. What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 1. Epidemiology, mechanisms of disease and methodological issues. Clin Exp Dermatol, 40, 238-42.

MADHOK, V., FUTAMURA, M., THOMAS, K. S. & BARBAROT, S. 2015. What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention. Clin Exp Dermatol, 40, 349-55.

NANKERVIS, H., DEVINE, A., WILLIAMS, H. C., INGRAM, J. R., DONEY, E., DELAMERE, F., SMITH, S. & THOMAS, K. S. 2015. Validation of the global resource of eczema trials (GREAT database). BMC Dermatol, 15, 4.

WHITTON, M. E., PINART, M., BATCHELOR, J.EZZEDINE, K. et al 2015. Interventions for vitiligo. Cochrane Database Syst Rev, 2, CD003263.

WILLIAMS, H. C., BURDEN-TEH, E. & NUNN, A. J. 2015. What is a pragmatic clinical trial? J Invest Dermatol, 135, e33.



WARBURTON KL, MCPHEE MJ, SAVAGE LJ, HONAN AE, MONTGOMERY R, GHAZAVI M, TORLEY D, SHAMS K and INGRAM JR, 2014. Management of morphoea: results of a national survey of UK clinicians. The B J Dermatol.

Bath-Hextall, F., Ozolins, M., Armstrong, S. J., et al (2014) Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. Lancet Oncol, 15, 96-105.

Eleftheriadou, V., Thomas, K., Ravenscroft, J., et al (2014) Feasibility, double-blind, randomised, placebo-controlled, multi-centre trial of hand-held NB-UVB phototherapy for the treatment of vitiligo at home (HI-Light trial: Home Intervention of Light therapy). Trials, 15, 51.

Ingram, J. R., Abbott, R., Ghazavi, M., et al (2014) The Hidradenitis Suppurativa Priority Setting Partnership. Br J Dermatol.

Kassim, J. M., Shipman, A. R., Szczecinska, W., et al (2014) How effective is intralesional injection of triamcinolone acetonide compared with topical treatments in inducing and maintaining hair growth in patients with alopecia areata? A Critically Appraised Topic. Br J Dermatol, 170, 766-771.

Layfield, C., Yong, A., Thomas, K., et al (2014) The UK Dermatology Clinical Trials Network – how far have we come? . Clin Investig (Lond), 4, 209-214.

Mason, J. M., Thomas, K. S., Crook, A. M., et al (2014) Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials. PLoS One, 9, e82694.



Thomas KS, Crook AM, Nunn, AJ, Foster KA, et al. Penicillin to prevent recurrent leg cellulitis. New England Journal of Medicine May 2013: 368:1695-1703 View abstract here.

Matin, R. N., Batchelor, J. M., Flohr, C., et al (2013) The UK Dermatology Clinical Trials Network Trainee Group: developing evidence-based practice and research engagement among dermatology trainees. Br J Dermatol, 169, 35.

Mitchell, E. J. (2010) RCT of treatments for pyoderma gangrenosum: time to get involved. Wounds UK, 6, 27-32.

Simpson, R. C., Thomas, K. S., Leighton, P., et al (2013) Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise. Br J Dermatol, 169, 337-343.

Simpson, R. C., Thomas, K. S. & Murphy, R. (2013) Outcome measures for vulval skin conditions: a systematic review of randomized controlled trials. Br J Dermatol, 169, 494-501.



Batchelor JM, Ridd MJ, Clarke T, Ahmed A, Cox M, Crowe S. et al The Eczema Priority Setting Partnership: A collaboration between patients, carers, clinicians and researchers to identify and prioritise important research questions for the treatment of eczema. Br J Dermatol 2012

Bath-Hextall FJ, Jenkinson C, Humphries R and Williams HC.  Dietary supplements for established atopic eczema. Cochrane Database of Systematic Reviews 2012 Feb 15; 2:CD005205.

Bratton DJ, Nunn AJ, Wojnarowska F, Kirtschig G, Sandell  A, Williams HC.  The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study. Trials 2012, 13:50

Cheng S, Kirtschig G, Cooper S, Thornhill M, Leonardi-Bee J, Murphy R. Interventions for erosive lichen planus affecting mucosal sites. Cochrane Database Syst Rev. 2012 Feb 15; 2:CD008092. Review. PMID: 22336835

Craig FF, Thomas KS, Mitchell EJ, Williams HC, Norrie J, Mason JM, and Ormerod AD. UK Dermatology Clinical Trials Network's STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial. Trials 2012;  13(1), 51.

Eleftheriadou V, Thomas KS, Whitton ME, Batchelor  JM, and Ravenscroft  JC, 2012. Which outcomes should we measure in vitiligo? Results of a systematic review and a survey amongst patients and clinicians on outcomes in vitiligo trials. Br J Dermatol. epub ahead of publication, Doi: 10.1111/j.1365-2133.2012.11056.x

Lansbury L, Bath-Hextall F. What’s new in skin cancer? An evidence –based update. Dermatological Nursing 2012; 11:37-39

Lawton S. and LIittlewood S. Vulval Skin Conditions- Disease activity and Quality of Life.  J Lower Gen Tract Dis 2012 (in press)

Patelan, Langan SM, and Batchelor  JM. A Randomized Trial Of Methotrexate Vs. Azathioprine For Severe Atopic Eczema: A Critical Appraisal. The British Journal Of Dermatology. 2012; 166(4), 701-3Doi: 10.1111/j.1365-2133.2012.10872.x

Simpson RC, Littlewood SM, Cooper SM, Cruickshank ME, Green CM, Derrick E, Yell J, Chiang N, Bell H, Owen C, Javed A, Wilson CL, McLelland J and Murphy R. Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit. Br J Dermatol. 2012 Jul;167(1):85-91. doi:10.1111/j.1365-2133.2012.10919.x. Epub 2012 Jun 6. PMID: 22384934

Tinelli M, Ozolins M, Bath-Hextall FJ  and WilliamsHC. What determines patient preferences for treating basal cell carcinoma? A discrete choice experiment survey from the SINS trial (surgery vs imiquimod). BMC Dermatology 2012; MS : 4902168727336740

UK Dermatology Clinical Trials Network’s PATCH Trial Team, Thomas K, Crook A, Foster K, Mason J, Chalmers J, Bourke J, Ferguson A, Level N, Nunn A and Williams H. Prophylactic antibiotics for the prevention of cellulitis (erysipelas) of the leg: results of the UK Dermatology Clinical Trials Network's PATCH II trial. Br J Dermatol. 2012; 166:169-78.

Williams HC. Commentary: are methotrexate and azathioprine really equivalent for treating severe atopic eczema? Br J Dermatol. 2012; 166:705-7.

Wootton CI, Koller K, Lawton S, O’Leary C, Thomas KS on behalf of SWET study team (2012) In Press Araccelerometers a useful tool for measuring scratch in children with eczema? Validity, responsiveness to change, and acceptability of use in a clinical trial setting. Br J Dermatol 2012



Bath-Hextall FJ, Birnie AJ, Ravenscroft  JC, Williams HC. Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated systematic review. Br J Dermatol 2011; 163: 12-26.

Davies RF, Ravenscroft J, Hashimoto T, Evans JH, Harman KE. Bullous pemphigoid associated with renal transplant rejection. Clin Exp Derm 2011 Oct; 36(7):824-5

Eleftheriadou V, Whitton M E, Gawkrodger D J, Batchelor J, Corne J, Lamb B, Ersser S, Ravenscroft  J, and Thomas KS. On behalf of the vitiligo priority setting partnership. Future research into the treatment of vitiligo: where should our priorities lie? Results of the vitiligo priority setting partnership. Br Dermatol 2011; 164(3), 530-536

Ewence A, Rumsby P, Rockett L, Davey W, Williams HC, Danby S, Cork M. A Review of Skin Irritation and Tap Water Quality. Drinking Water Inspectorate, DEFRA, WRc Ref: DWI8375.01, March 2011

Flohr C, Aikhaled N, Nagele G, Weinmayr G, Williams HC, Kleiner A, Strachan D. Lack of evidence for a protective effect of prolonged breastfeeding on childhood eczema: Lessons from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two. Br J Dermatol 2011; 165: 1280-1289.

Foisy M, Boyle RJ, Chalmers JR, Simpson EL, Williams HC. The prevention of eczema in infants and children:  an overview of Cochrane and non-Cochrane reviews. Evidence-Based Child Health 2011; 6: 1322-1339

Lawton S.  Atopic Eczema and Evidence Based Care. Journal Dermatology Nursing Association 2011; 3, (3)13-39 USA

Lawton S. Eczema In Schools. Saved by the Bell. Exchange June 2011, NES pp23-26

Lawton S. External influences on Skin Health. Nursing and Residential Care 2011; Vol 13: No11: Pg 522-526

Lawton S. Treatment options for managing psoriasis. Independent Nurse 2011;30-32

Layfield C, Clarke T, Thomas K, Williams HC. Developing a network in a neglected area of clinical research the UK Dermatology Clinical Trials Network. Clinical Investigation 2011; 1(7): 943-9.

Nankervis H, Maplethorpe A, Williams HC. Mapping randomised controlled trials of treatments for eczema - The GREAT database. BMC Dermatology 2011; 11:10.

Nankervis H, Maplethorpe A and Williams HC. Mapping randomized controlled trials of treatments for eczema - The GREAT database (The Global Resource of Eczema Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010). BMC Dermatology 2011; 11(1), 10

Ridd M, Thomas K, Wallace P, and O'Sullivan F. Dermatology research in primary care: why, what, and how? The British journal of general practice 2011; 61(583), 89-90

Schofield JK, Fleming D, Grindlay D, Williams H. Skin conditions are the commonest new reason people present to general practitioners in England and Wales. Br J Dermatol 2011; 165: 1044-50.

Schmitt  J, Langan S, Stamm T and Williams H on behalf of the harmonizing outcome measurements in eczema (HOME) Delphi panel. Core outcome domains for controlled trials and clinical recordkeeping in eczema: International multi-perspective Delphi consensus process. J Invest Dermatol 2011; 131:623-30.

Thomas KS, Koller K, Foster K, Perdue J, Charlesworth L, and Chalmers JR. The UK Clinical Research Network - has it been a success for dermatology clinical trials? Trials 2011; 12(1), 153

Thomas K, Koller K, Dean T, O'Leary C, Sach T, Frost A, Pallett I, Crook A, Meredith S, Nunn A, Burrows N, Pollock I, Graham-Brown R, O'Toole E, Potter D, Williams HC. A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children: the Softened Water Eczema Trial (SWET). Health Technol Assess. 2011;15: 1-156.

Thomas KS, Dean T, O'Leary C, Sach TH, Koller K, Frost A, Williams HC. A Randomised Controlled Trial of Ion-Exchange Water Softeners for the Treatment of Eczema in Children. PLoS Med 2011;8(2): e1000395. doi:10.1371/journal.pmed.1000395

Williams HC, Bath-Hextall F, Dewar D, Kelly C, Lansbury L, Lear J, Newton-Bishop J, Schofield J.

Improving outcomes for people with skin tumours including melanoma: Evidence Update October 2011. National Institute for Health and Clinical Excellence, October 2011

Williams HC. Preventing eczema flares with topical corticosteroids or tacrolimus: which is best? Br J Dermatol. 2011; 164:231-




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